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Wiley InterScience | ||
![]() Skin Research and TechnologyVolume 8 Issue 3, Pages 164 - 167 Published Online: 18 Sep 2002 © 2010 John Wiley & Sons A/S
Abstract | References | Full Text: HTML, PDF (Size: 83K) | Related Articles | Citation Tracking Split face study on the cutaneous tensile effect of 2-dimethylaminoethanol (deanol) gel Copyright © Blackwell Munksgaard, 2002 KEYWORDS Dimethylaminoethanol • shear wave propagation • tensile strength • acetylcholine ABSTRACTBackground/aims:Beyond subjective assessments, the effect of skin tensors is difficult to assess. The present 2-phase randomized double-blind split face study was designed to compare the effect of a gel containing 3% 2-dimethylaminoethanol (deanol, DMAE) with the same formulation without DMAE. Methods:In a first pilot study, sensorial assessments and measures of the skin distension under suction were performed in eight volunteers. In a second study conducted in 30 volunteers, shear wave propagation was measured. Results:Large interindividual variations precluded any significant finding in the first study. The DMAE formulation showed, however, a significant effect characterized by increased shear wave velocity in the direction where the mechanical anisotropy of skin showed looseness. Conclusion:The DMAE formulation under investigation increased skin firmness. |