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Wiley InterScience | ||||||
  Australasian Journal of DermatologyVolume 43 Issue 4, Pages 247 - 254 Published Online: 29 Nov 2002 Journal compilation © 2010 The Australasian College of Dermatologists
Abstract | References | Full Text: HTML, PDF (Size: 141K) | Related Articles | Citation Tracking  PERSONAL REVIEW Atopic dermatitis: Review of immunopathogenesis and advances in immunosuppressive therapy Linton J Meagher, MB BS. Nina Y Wines, MB BS. Alan Cooper, FACD. Copyright 2002 Blackwell Publishing Asia Pty Ltd KEYWORDS azathioprine • corticosteroids • cyclosporin • eczema • immunosuppression • pimecrolimus • tacrolimus ABSTRACTThis paper reviews the theories of the pathogenesis of atopic dermatitis (AD), with a particular emphasis on its immunopathogenesis. The contribution of predisposing factors, immunopathogenic factors and provoking factors in the pathogenesis of AD are considered. Predisposing factors explored in this article include genetics and the disturbance of skin function. Immunopathogenic factors reviewed include T cell dysfunction, biphasic cytokine expression and the role of immunoglobulin E. Provoking factors considered include microbial factors, psychosomatic interactions, contact allergens and irritants, inhalant allergens, food and climate. Immunosuppressive treatments reviewed include cyclosporin, azathioprine, methotrexate, tacrolimus, interferon-γ, phosphodiesterase inhibitors and pimecrolimus (SDZ ASM 981). Submitted 22 August 2000; accepted 25 April 2002. | 
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