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Wiley InterScience | |||||||||||||
  Journal of Eukaryotic MicrobiologyVolume 49 Issue 6, Pages 475 - 477 Published Online: 11 Jul 2005 © 2010 The International Society of Protistologists
Abstract | References | Full Text: HTML, PDF (Size: 312K) | Related Articles | Citation Tracking  Induction of Anti-Actin Drug Resistance in Tetrahymena Copyright 2002 by the Society of Protozoologists KEYWORDS Actin • ciliates • cytochalasin • cytoskeleton • endocytosis • food vacuoles • latrunculin • microfilaments • multidrug resistance • phagocytosis ABSTRACTABSTRACT Both cytochalasin D and latrunculin B reversibly inhibited Tetrahymena phagocytosis at concentrations similar to those effective in mammalian systems, even though ciliate actins are known to be highly divergent from mammalian actins. Overnight exposure to relatively low (0.25 μM) concentrations of latrunculin B induced resistance in Tetrahymena to the inhibitory effects of that drug, as well as cross-resistance to cytochalasin D. However, much higher (>30 μM) concentrations of cytochalasin D were required for induction of cross-resistance to latrunculin B. Anti-actin drug resistance in Tetrahymena may involve a general multidrug resistance mechanism and/or specific feedback regulation of F-actin assembly and stability. Received 10/13/01, 05/14/02, 09/09/02; accepted 09/09/02 | 
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