|
If you are seeing this message, you may be experiencing temporary network problems. Please wait a few minutes and refresh the page. If the problem persists, you may wish to report it to your local Network Manager.
It is also possible that your web browser is not configured or not able to display style sheets. In this case, although the visual presentation will be degraded, the site should continue to be functional. We recommend using the latest version of Microsoft or Mozilla web browser to help minimise these problems.
Wiley InterScience | ||||||||||||||
  Journal of Applied MicrobiologyVolume 90 Issue 4, Pages 550 - 554 Published Online: 21 Dec 2001 Journal compilation © 2010 The Society for Applied Microbiology The Official Journals of the Society for Applied Microbiology
Abstract | References | Full Text: HTML, PDF (Size: 109K) | Related Articles | Citation Tracking  Activation of clindamycin phosphate by human skin Copyright The Society for Applied Microbiology ABSTRACTAims: To investigate the relative antimicrobial activity of clindamycin phosphate (CP) and clindamycin (Cly) and to examine the effect of skin homogenates on the activity of CP. Methods and Results: Minimum inhibitory concentrations (MIC) were determined against dermally relevant organisms and bactericidal activity was studied using time-kill methodology. The effect of skin homogenates on the antimicrobial activity of CP was studied by well-diffusion assay. The MIC of Cly was substantially lower than that of CP in all susceptible organisms. Clindamycin also showed greater bactericidal activity (rate of kill) than CP. Phosphatases in skin homogenates activated CP at pH 4–8 with a maximal activation at pH 4. Conclusions: Phosphatases within the skin have been shown to convert CP to the more potent form Cly. Significance and Impact of the Study: Conversion to Cly is a major determinant of antimicrobial activity in the skin layers following topical application of CP.
| 
|
|
 |
 |
 |
