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Allergic Reactions Due to Ibuprofen in Children
M. Díaz JaraM.D. , A. Pérez MonteroM.D. , M. T. Gracia BaraM.D. , S. CabrerizoM.D. , L. ZapateroM.D. , and M. I. Martínez MoleroM.D.
  Pediatric Allergology Section, "Gregorio Marañón" U.G. Hospital, Madrid, Spain
Address correspondence to M. Díaz Jara, M.D., C/Las Cañas 4, 3°A, Madrid 28043, Spain, or e-mail:mdiazj@meditex.es.
Copyright Blackwell Science, Inc.

ABSTRACT

Abstract: Ibuprofen is 2-(4-isobutyl-fenyl)-propionic acid, which belongs to the same group of nonsteroidal antiinflammatory drugs (NSAIDs) as naproxen and ketoprofen. We present two instances of adverse reaction to pediatric ibuprofen, an acute urticaria and a fixed drug eruption, with tolerance to acetylsalicylic acid (ASA) and acetaminophen, in what seems to be hypersensitivity to the propionic acid group. Although these reactions are very rare and ibuprofen is still very safe, we think it is important to know about the possible side effects in order to recognize and treat them when they occur.


DIGITAL OBJECT IDENTIFIER (DOI)
10.1046/j.1525-1470.2001.018001066.x About DOI

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