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Mitochondrial Inheritance in Budding Yeast
Istvan R. Boldogh , Hyeong-Cheol Yang and Liza A. Pon*
  Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
*Corresponding author: Liza A. Pon, lap5@columbia.edu
Copyright Munksgaard
KEYWORDS
actin • cytoskeleton • mitochondrial membranes • organelle inheritance • organelle motility

ABSTRACT

During the past decade significant advances were made toward understanding the mechanism of mitochondrial inheritance in the yeast Saccharomyces cerevisiae. A combination of genetics, cell-free assays and microscopy has led to the discovery of a great number of components. These fall into three major categories: cytoskeletal elements, mitochondrial membrane components and regulatory proteins. These proteins mediate activities, including movement of mitochondria from mother cells to buds, segregation of mitochondria and mitochondrial DNA, and equal distribution of the organelle between mother cells and buds during yeast cell division.


Received and accepted for publication 2 April 2001

DIGITAL OBJECT IDENTIFIER (DOI)
10.1034/j.1600-0854.2001.002006368.x About DOI

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