Hardy–Weinberg quality control

doi:10.1046/j.1469-1809.1999.6360535.x

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Wiley InterScience

Annals of Human Genetics

Volume 63 Issue 6, Pages 535 - 538

Published Online: 24 Feb 2003

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Hardy–Weinberg quality control

I. GOMES ¹ , A. COLLINS ¹ , C. LONJOU ¹ , N. S. THOMAS ¹ , J. WILKINSON ¹ , M. WATSON ¹ N. MORTON ¹

¹ Human Genetics, University of Southampton, Duthie Building, Southampton General Hospital, Tremona Road, Southampton, U.K.

Correspondence to N. Morton, Human Genetics, University of Southampton, Duthie Building, Southampton General Hospital, Tremona Road, Southampton, U.K. Tel: +44 (0) 23 8079 6535; Fax: +44 (0) 23 8079 4264. E-mail: nem@soton.ac.uk

ABSTRACT

An efficient test of deviation from Hardy–Weinberg frequencies with one degree of freedom was applied to 44 marker loci in a genome scan, and 7 loci had a significant excess of apparent homozygotes (χ²₍₁₎ > 6) suggestive of typing error. In this example evidence for linkage did not increase when outliers were censored. Statistical quality control is an essential part of genotyping, and the effect of mistyping and map error should be considered in evaluating any genome scan.

Received: 10 June 1999; Accepted: 15 October 1999;

DIGITAL OBJECT IDENTIFIER (DOI)

10.1046/j.1469-1809.1999.6360535.x About DOI