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Wiley InterScience | |||||||||||
  Clinical GeneticsVolume 56 Issue 2, Pages 142 - 144 Published Online: 24 Dec 2001 © 2010 John Wiley & Sons A/S
Abstract | References | Full Text: HTML, PDF (Size: 112K) | Related Articles | Citation Tracking  Possible interaction of genotypes at cystathionine β-synthase and methylenetetrahydrofolate reductase (MTHFR) in neural tube defects Copyright Munksgaard 1999 KEYWORDS cystathionine beta-synthase • methylenetetrahydrofolate reductase • neural tube defects ABSTRACTNeural tube defects are a common, complex disorder with genetic and environmental components to risk. We investigated the previously reported interaction between homozygosity for the thermolabile variant at the methylenetetrahydrofolate reductase and heterozygosity for the 844ins68 allele at the cystathionine β-synthase loci in cases with lumbosacral myelomeningocele and their parents. Using control allele frequencies from our sample pooled with those published in the literature, we confirm a marginally significant interaction at these two loci. This finding suggests that additional, larger studies are warranted to investigate this possible interaction in more detail. Received 8 February 1999 | 
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