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Wiley InterScience | |||||||||||||||||
  Veterinary SurgeryVolume 28 Issue 4, Pages 219 - 225 Published Online: 29 Apr 2004 © 2010 American College of Veterinary Surgeons
Abstract | References | Full Text: HTML, PDF (Size: 60K) | Related Articles | Citation Tracking  Antibacterial Properties of a Silver Chloride-Coated Nylon Wound Dressing Address reprint requests to A.P. Adams, DVM, James A. Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853. Copyright 1999 by The American College of Veterinary Surgeons ©Copyright 1999 by The American College of Veterinary Surgeons ABSTRACTObjective—A silver chloride-coated nylon wound dressing (Ag-WD) was evaluated in vitro for antimicrobial activity against five common equine wound pathogens. Study Design—Bacterial susceptibility study. Sample Population—Equine wound pathogens: Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Streptococcus equi subspecies zooepidemicus, and Staphylococcus aureus. Methods—An inoculum of each pathogen was incubated directly with Ag-WD and quantitated after 24 to 48 hours of incubation. To determine if bactericidal activity of Ag-WD was contact dependent, an inoculum of E. coli and Staphylococcus aureus was incubated separately from Ag-WD by a filter and quantitated after 18 hours of incubation. Inductively coupled plasma emission spectrometry (ICP) determined the silver concentration of Mueller-Hinton broth containing Ag-WD after 24 hours of incubation. To establish if the rate of bacterial killing by Ag-WD differed from a constant silver concentration, pathogens were exposed to a silver concentration of 6.45 μg/mL and quantitated after 18 hours. Results—Direct exposure to Ag-WD significantly reduced bacterial numbers after 15 minutes for K. pneumoniae, 30 minutes for E. coli, 1 hour for P. aeruginosa, and 2 hours for S. equi subspecies zooepidemicus and Staphylococcus aureus. Indirect exposure to Ag-WD resulted in ≥99.9% and ≥90% kill of the inoculum doses of E. coli at 2 hours and Staphylococcus aureus at 18 hours, respectively. Incubation of the pathogens at the constant silver concentration resulted in bacterial killing rates similar to those obtained by incubation with Ag-WD. Conclusions—In vitro, equine pathogens are effectively killed when exposed to Ag-WD, and the rate of bacterial killing by Ag-WD is similar to a constant silver concentration of 6.45 μg/mL. Clinical Relevance—The in vitro antimicrobial properties of this silver-coated nylon wound dressing are promising for future prevention of equine wound infections. | 
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