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Wiley InterScience | ||||||
  Journal of Internal MedicineVolume 246 Issue 6, Pages 591 - 592 Published Online: 25 Dec 2001 © 2010 Blackwell Publishing Ltd
Abstract | References | Full Text: HTML, PDF (Size: 70K) | Related Articles | Citation Tracking  CASE REPORT Chronic intoxication by doxycycline use for more than 12 years Copyright Blackwell Science Ltd, 1999 KEYWORDS adverse events • chronic intoxication • doxycycline • long-term treatment • side-effects ABSTRACTAbstract. Westermann GW, Böhm M, Bonsmann G, Rahn KH, Kisters K (Westfälische Wilhelms-University, Münster, Germany). Chronic intoxication by doxycycline use for more than 12 years (Case Report). J Intern Med 1999; 246: 591–592. We report the clinical case of a 12-years' intoxication by doxycycline. A patient with a depersonalization and derealization syndrome took 1 g doxycycline per day. In addition to hepatocellular necrosis with cholestasis, nephrotoxicity, leukopenia, anaemia and skin hyperpigmentation he suffered from hitherto unreported adverse cardiac events as intermittent supraventricular tachycardia and sporadic Wenckebach heart block. Despite a long period of self-medication these side-effects were reversible. Received: 01 March 1999; Accepted: 16 June 1999; | 
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