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Modification of Subcutaneous Adipose Tissue by a Methylxanthine Formulation: A Double-Blind Controlled Study
Tim Lesser, BS, Ed Ritvo, MD, and Lawrence S. Moy, MD
  Manhattan Beach, California
Address correspondence and reprint requests to: Lawrence S. Moy, MD, 1101 N. Sepulveda Blvd., Suite 100, Manhattan Beach, CA 90266.
Copyright 1999 American Society for Dermatologic Surgery

ABSTRACT

Background. Excessive subcutaneous adipose tissue is typically treated by physically removing the fat through liposuction, but cost and accessibility have popularized alternative treatments for reducing adipose tissue thickness.

Objective. The purpose of this study was to test the absolute and relative effectiveness of a liposome-encapsulated caffeine-based cream in modifying subcutaneous adipose tissue.

Methods. Forty-one patients consented and completed the double-blind, single-center, placebo-controlled study. Caliper measurements, tape measurements, and photographs were taken over a 2-month period.

Results. Both concentrations of the cream were found to significantly reduce the thickness of the adipose tissue in all areas of the body. In addition, the more concentrated cream was significantly more effective than the less concentrated cream in the areas of the hips and the triceps.

Conclusion. The caffeine-based liposome-encapsulated cream significantly reduced the thickness of the subcutaneous fat over a 2-month period.


DIGITAL OBJECT IDENTIFIER (DOI)
10.1046/j.1524-4725.1999.08243.x About DOI

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