Preoperative and Postoperative Topical Tretinoin on High-Tension Excisional Wounds and Full-Thickness Skin Grafts in a Porcine Model: A Pilot Study

doi:10.1046/j.1524-4725.1999.99005.x

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Wiley InterScience

Dermatologic Surgery

Volume 25 Issue 9, Pages 716 - 721

Published Online: 24 Dec 2001

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Preoperative and Postoperative Topical Tretinoin on High-Tension Excisional Wounds and Full-Thickness Skin Grafts in a Porcine Model: A Pilot Study

Clark C. Otley, MD,* Scott M. Gayner, MD, ^† Iftikhar Ahmed, MD,* Eric J. Moore, MD, ^† Randall K. Roenigk, MD,* and David A. Sherris, MD ^†

*Departments of Dermatology and ^† Otorhinolaryngology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota

Address correspondence and reprint requests to: Clark C. Otley, MD, Department of Dermatology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905.

ABSTRACT

Background. Tretinoin induces neovascularization and the formation of collagen when applied topically.

Objective. The goal was to determine whether preoperative and postoperative treatment with tretinoin enhances the healing of high-tension, full-thickness excisional wounds and the survival of full-thickness skin grafts.

Methods. A blinded, randomized, placebo-controlled pilot study involved high-tension excisional wounds and full-thickness skin grafts treated perioperatively with tretinoin in a porcine model.

Results. Perioperative treatment of high-tension excisional surgery sites with tretinoin appeared to have no consistent beneficial or adverse effects on wound healing or scar spreading. In the full-thickness skin graft model, a trend toward impaired wound healing was noted.

Conclusion. The collagen-inducing effects of topical tretinoin do not appear to enhance the healing of high-tension excisional surgery wounds in a porcine model. Tretinoin does not appear to improve the survival of full-thickness skin grafts and, in fact, a detrimental effect was apparent in our model.

DIGITAL OBJECT IDENTIFIER (DOI)

10.1046/j.1524-4725.1999.99005.x About DOI