Cutaneous adverse effects associated with terbinafine therapy: 10 case reports and a review of the literature

doi:10.1046/j.1365-2133.1998.02140.x

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Wiley InterScience

British Journal of Dermatology

Volume 138 Issue 3, Pages 529 - 532

Published Online: 4 Jan 2002

An Official Journal of the British Association of Dermatologists

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Cutaneous adverse effects associated with terbinafine therapy: 10 case reports and a review of the literature

Gupta, Lynde, Lauzon, Mehlmauer, Braddock, Miller, Del Rosso & Shear

⁰ Division of Dermatology, Department of Medicine, Sunnybrook Health Science Center and the University of Toronto, Toronto, Canada, ¹ Division of Dermatology, Department of Medicine, Toronto Western Hospital and the University of Toronto, Toronto, Canada, ² Division of Dermatology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada, ³ Pasadena CA, U.S.A., ⁴ Braddock Dermatology Clinic, Omaha, NB, U.S.A., ⁵ Burlingame CA, U.S.A., ⁶ Las Vegas Skin and Cancer Clinics, Las Vegas, NV, U.S.A., ⁷ Divisions of Dermatology and Clinical Pharmacology, Department of Medicine and Pharmacology, Sunnybrook Health Science Center and the University of Toronto, Toronto, Canada

ABSTRACT

Terbinafine is an allylamine antifungal agent widely used to treat dermatophyte onychomycosis and dermatomycoses. We report 10 severe cutaneous adverse reactions associated with terbinafine therapy which required discontinuation of the antifungal agent: erythema multiforme (five patients), erythroderma (one), severe urticaria (one), pityriasis rosea (one) and worsening of pre-existing psoriasis (two patients). The spectrum of cutaneous adverse effects associated with terbinafine therapy is reviewed. Patients should be counselled about discontinuing terbinafine at the onset of a cutaneous eruption and about seeking medical advice about further management.

DIGITAL OBJECT IDENTIFIER (DOI)

10.1046/j.1365-2133.1998.02140.x About DOI