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Wiley InterScience | ||||||
  British Journal of Clinical PharmacologyVolume 46 Issue 1, Pages 45 - 48 Published Online: 4 Jan 2002 Journal compilation © 2010 The British Pharmacological Society The Journal of The British Pharmacological Society
Abstract | References | Full Text: HTML, PDF (Size: 76K) | Related Articles | Citation Tracking  Early lung absorption profile of non-CFC salbutamol via small and large volume plastic spacer devices Copyright 1998 Blackwell Science Ltd KEYWORDS lung delivery • non-CFC metered dose inhaler • salbutamol • small and large volume plastic spacers ABSTRACTAims To evaluate the lung dose of a non-CFC salbutamol metered dose inhaler (MDI) formulation via three commonly used plastic spacer devices, of both large and small volume, compared with the MDI used on its own.
Methods
Ten healthy volunteers were studied in a randomized single (investigator) blind crossover design. Single 1200 μg nominal doses of salbutamol from a non-CFC MDI (Airomir), as 12 sequential 100 μg puffs over 6 min, were delivered from the MDI alone and via two large volume spacer devices (Nebuhaler, Volumatic), and a small volume spacer (Aerochamber). All spacers were prewashed prior to each study day and mouth rinsing was performed after each drug sequence. Plasma salbutamol was measured at 5, 10, 15 and 20 min, with calculation of maximum (C
Results
Both of the large volume spacers, the Nebuhaler and the Volumatic, delivered significantly more salbutamol than the MDI alone. For C Conclusions Using the early lung absorption profile, for administration of the same nominal dose, both of the large volume spacers (Nebuhaler and Volumatic) but not the small volume spacer (Aerochamber) delivered significantly more salbutamol than the MDI alone. The Nebuhaler also produced greater delivery than either the Volumatic or the Aerochamber spacer devices. Our results show that whilst lung delivery of non-CFC salbutamol MDI is improved by the use of a plastic spacer, there may be appreciable differences in performance, particularly between large and small volume devices.
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