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Wiley InterScience | |||||||
  Alimentary Pharmacology & TherapeuticsVolume 11 Issue 6, Pages 1047 - 1052 Published Online: 2 Oct 2003 Journal compilation © 2010 Blackwell Publishing Ltd
Abstract | Full Text: PDF (Size: 123K) | Related Articles | Citation Tracking  Oral budesonide therapy for steroid-dependent ulcerative colitis: a pilot trial Copyright 1997 Blackwell Science Ltd. ABSTRACTBackground:Budesonide, a corticosteroid with high topical anti-inflammatory activity and low systemic activity, has been shown to prolong time to relapse in Crohn's disease. In the present study, the efficacy of budesonide in an oral pH-modified-release formulation was evaluated for maintenance treatment in patients with steroid-dependent ulcerative colitis. Methods:Fourteen patients with steroid-dependent ulcerative colitis in the reduction phase of conventional glucocorticosteroids (c-GCS) following a severe attack, were treated with budesonide 3 mg t.d.s. for 6 months. The primary investigation parameters were changes in the clinical activity index (CAI) and in the daily dose of c-GCS. Results:In 11 cases the CAI improved significantly and treatment with c-GCS could be terminated. Three patients experienced relapse and needed further c-GCS treatment. The average daily dose of c-GCS and the average value of the CAI before treatment with budesonide were significantly higher in the relapse group than in the remission group. Conclusions:In patients with c-GCS-dependent ulcerative colitis, a dose of 9 mg budesonide daily in an oral pH-modified-release formulation was well tolerated, significantly decreased the CAI, and rendered c-GCS unnecessary in the majority of cases.
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