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Wiley InterScience | |||||||||
  Clinical EndocrinologyVolume 46 Issue 2, Pages 203 - 207 Published Online: 29 Oct 2003 © 2010 Blackwell Publishing Ltd The Clinical Journal of the Society for Endocrinology
Abstract | Full Text: PDF (Size: 266K) | Related Articles | Citation Tracking  Effect of low dose oxandrolone and testosterone treatment on the pituitary-testicular and GH axes in boys with constitutional delay of growth and puberty ABSTRACTOBJECTIVE To investigate the effect of low dose oxandrolone and testosterone on the pituitary- testicular and GH-IGF-I axes. DESIGN Prospective double-blind placebo-controlled trial. PATIENTS Sixteen boys with constitutional delay of growth and puberty (CDGP) with testicular volumes 4–6 ml were randomized to 3 months treatment: Group 1 (n = 5), daily placebo: Group 2 (n = 5), 2.5 mg oxandrolone daily or Group 3 (n = 6), 50 mg testosterone monthly intramuscular injections with assessment (growth, pubertal development and overnight hormone profiles) at 0, 3, 6 and 12 months. MAIN OUTCOME MEASURES LH and GH profiles (15-minute samples) were analysed by peak detection (Pulsar), Fourier transformation and autocorrelation. Testosterone levels were measured hourly and insulin, SHBG, IGF-I, and IGFBP-3 levels at 0800 h. Statistical analysis was by multivariate analysis of variance for repeated measures. RESULTS LH and testosterone parameters increased significantly with time in all 16 (LH AUC, P < 0.0001; peak amplitude, P = 0.02; number of peaks, P = 0.02; testosterone AUC, P = 0.02; morning testosterone, P = 0.002). In Group 2, however, LH and testosterone parameters decreased at 3 months followed by a rebound increase at 6 and 12 months. SHBG levels were markedly reduced at 3 months (P = 0.006) and a wider range of dominant GH frequencies was present although GH AUC was not increased until 6 months, with an increase in GH pulse frequency but not amplitude. IGF-I levels were increased at both 3 and 12 months. In Group 3, pituitary-testicular suppression was not apparent, but GH levels increased with an increase in GH amplitude at 3 and 12 months. CONCLUSION Oxandrolone transiently suppressed the pituitary-testicular axis and altered GH pulsatility. Testosterone increased GH via amplitude modulation.
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