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Wiley InterScience | ||||||
  British Journal of Clinical PharmacologyVolume 44 Issue 2, Pages 175 - 178 Published Online: 2 Oct 2003 Journal compilation © 2010 The British Pharmacological Society The Journal of The British Pharmacological Society
Abstract | Full Text: PDF (Size: 293K) | Related Articles | Citation Tracking  Omeprazole, other antiulcer drugs and newly diagnosed gout KEYWORDS omeprazole • ranitidine • cimetidine • gout ABSTRACTAims Case-reports describing patients who developed a first episode of acute gout while being treated with the proton pump inhibitor omeprazole led us to compare incidence rates of newly diagnosed gout cases among omeprazole, ranitidine and cimetidine users. Methods We conducted a cohort study with a nested case-control analysis using the UK-based General Practitioner Research Database (GPRD). The study encompassed a cohort of more than 53 000 subjects who received some 185 000 prescriptions for the three study drugs.
Results Neither current omeprazole vs recent use (age- and sex-adjusted relative risk 1.1, 95% CI 0.5–2.1), nor current omeprazole use in comparison with current use of the two histamine H Conclusions While other known risk factors were significantly associated with gout, current omeprazole use was not materially associated with an increased gout incidence.
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