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Wiley InterScience | ||||||
  British Journal of Clinical PharmacologyVolume 44 Issue 2, Pages 179 - 182 Published Online: 2 Oct 2003 Journal compilation © 2010 The British Pharmacological Society The Journal of The British Pharmacological Society
Abstract | Full Text: PDF (Size: 308K) | Related Articles | Citation Tracking  Is metronidazole teratogenic? A meta-analysis KEYWORDS metronidazole • malformations • meta-analysis ABSTRACTAim In order to assess whether the use of metronidazole during pregnancy is associated with a higher risk of congenital malformations, a meta-analysis was conducted. Methods All epidemiological studies (cohort and case-control) which estimate risk of congenital malformations after exposure to metronidazole during early pregnancy were included in the meta-analysis. To obtain a summary odds ratio, the Mantel-Haenszel method was used. A test to verify absence of heterogeneity was also performed.
Results One unpublished case-control and four published cohort studies fulfilled the inclusion criteria and were not statistically heterogeneous. A summary odds ratio was calculated for metronidazole exposure during the first trimester: OR=1.08, 95% CI: 0.90–1.29, heterogeneity test χ Conclusions This meta-analysis did not find any relationship between metronidazole exposure during the first trimester of pregnancy and birth defects.
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