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Wiley InterScience | ||||||
  Clinical and Experimental Pharmacology and PhysiologyVolume 27 Issue 9, Pages 715 - 723 Published Online: 24 Dec 2001 Journal compilation © 2010 Blackwell Publishing Asia Pty Ltd
Abstract | References | Full Text: HTML, PDF (Size: 461K) | Related Articles | Citation Tracking  Acute And Chronic Sympathoinhibition On Carotid Artery Diameter Of Spontaneously Hypertensive Rats: Effects Of Clonidine And Flesinoxan Copyright Blackwell Science Asia Pty. Ltd. KEYWORDS carotid artery diameter • centrally acting antihypertensive agents • chronic treatments • conscious animal • spontaneously hypertensive rats ABSTRACTSUMMARY1. Hypertensive conduit arteries are thicker and stiffer than those of normotensive controls. Whether they are specifically sensitive to central sympathoinhibition has never been investigated. 2. The effects of acute (24 h infusion) and chronic (4 week infusion) treatments with clonidine (0.01 and 0.1 mg/kg per day) and flesinoxan (1 and 3 mg/kg per day) on carotid artery diameter were investigated in spontaneously hypertensive rats. At the end of treatment, blood pressure (BP) was recorded in the rats while they were conscious. Rats were then anaesthetized for carotid artery diameter measurements using an ultrasonic echo-tracking device. 3. In conscious rats, clonidine significantly decreased BP and heart rate (HR) following acute but not chronic treatment. In contrast, flesinoxan significantly decreased BP following both the acute and chronic treatment. In anaesthetized animals, the two agents have opposite effects on isobaric carotid artery diameter, with a decrease under clonidine and an increase under flesinoxan. After 4 weeks infusion, the reactivity of aortic rings was studied in organ chambers. Flesinoxan, but not clonidine, caused the relaxation of potassium chloride precontracted aortic segments. 4. The results indicate that although clonidine and flesinoxan are centrally acting antihypertensive agents, the drug-induced changes in isobaric carotid diameter may be influenced by local factors independent of the central action of the two drugs. | 
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