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Wiley InterScience | |||||||
  Psychiatry and Clinical NeurosciencesVolume 54 Issue 1, Pages 37 - 40 Published Online: 25 Dec 2001 Journal compilation © 2010 Japanese Society of Psychiatry and Neurology Official Journal of the Japanese Society of Psychiatry and Neurology
Abstract | References | Full Text: HTML, PDF (Size: 65K) | Related Articles | Citation Tracking  Effects of zolpidem and zopiclone on cognitive and attentional function in young healthy volunteers: An event-related potential study Copyright 1999 Blackwell Science Asia Pty. Ltd. KEYWORDS event-related potentials • mismatch negativity • negative difference • sleep latency test • zolpidem • zopiclone ABSTRACTAbstractThe effects of zolpidem and zopiclone, non-benzodiazepine ultra-short-acting hypnotics, on cognitive function and vigilance level were investigated in the morning following nocturnal administration using event-related potentials (ERP) and a sleep latency test (SLT). Zopiclone significantly shortened the sleep latency the following morning, whereas zolpidem did not, perhaps due to the difference in the elimination half-lives between the compounds. No significant effect was observed for either drug on the ERP indices, including the P3, mismatch negativity and negative difference components. At a clinically prescribed dosage these sleep inducers have no remarkable effect on cognitive or attentional functions but increase sleepiness of the subjects. | 
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