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Wiley InterScience | |||||||
  Dermatologic SurgeryVolume 31 Issue s1, Pages 860 - 866 Published Online: 21 Mar 2006 © 2010 American Society of Dermatologic Surgery
Abstract | References | Full Text: HTML, PDF (Size: 468K) | Related Articles | Citation Tracking  Niacinamide: A B Vitamin that Improves Aging Facial Skin Appearance This work was presented in part at the International Academy of Cosmetic Dermatology meeting in Beijing, China, December 2003, and at the American Academy of Dermatology annual meeting in Washington, DC, February 2004. Copyright 2005 American Society for Dermatologic Surgery, Inc. ABSTRACTBackground. In multiple chronic clinical studies, topical niacinamide (vitamin B3) has been observed to be well tolerated by skin and to provide a broad array of improvements in the appearance of aging facial skin (eg, reduction in the appearance of hyperpigmentated spots and red blotchiness). Objective. To clinically determine the effect of topical niacinamide on additional skin appearance and property end points (wrinkles, yellowing, and elasticity). Methods. Female white subjects ( N = 50 ) with clinical signs of facial photoaging (fine lines and wrinkles, poor texture, and hyperpigmented spots) applied 5% niacinamide to half of the face and its vehicle control to the other half twice daily for 12 weeks (double blind, left-right randomized). Facial images and instrumental measures were obtained at baseline and at 4-week intervals. Results. Analyses of the data revealed a variety of significant skin appearance improvement effects for topical niacinamide: reductions in fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness (yellowing). In addition, elasticity (as measured via cutometry) was improved. Corresponding mechanistic information is presented. Conclusion. In addition to previously observed benefits for topical niacinamide, additional effects were identified (improved appearance of skin wrinkles and yellowing and improved elasticity). ALL OF THE AUTHORS ARE EMPLOYED BY THE PROCTER & GAMBLE COMPANY, WHICH FUNDED THIS STUDY. | 
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