Enhancement of pressor response to ephedrine following clonidine medication

doi:10.1111/j.1365-2044.1996.tb07697.x

If you are seeing this message, you may be experiencing temporary network problems. Please wait a few minutes and refresh the page. If the problem persists, you may wish to report it to your local Network Manager.

It is also possible that your web browser is not configured or not able to display style sheets. In this case, although the visual presentation will be degraded, the site should continue to be functional. We recommend using the latest version of Microsoft or Mozilla web browser to help minimise these problems.

Systems Maintenance, Monday, 15th February 2010

Wiley InterScience

Anaesthesia

Volume 51 Issue 2, Pages 123 - 127

Published Online: 22 Feb 2007

Journal of the Association of Anaesthetists of Great Britain and Ireland

Go to Society Site

< Previous Abstract | Next Abstract >

Save Article to My Profile Download Citation Request Permissions

Abstract | References | Full Text: PDF (Size: 458K) | Related Articles | Citation Tracking

Enhancement of pressor response to ephedrine following clonidine medication

M. TANAKA MD ¹ , T. NISHIKAWA MD ² ,

¹ M. TANAKA MD, Staff Anaesthetist, Department of Anaesthesia/Critical Care Medicine, Tsuchiura Kyodo General Hospital, 11–7 Manabeshinmachi, Tsuchiura-shi, Ibaraki-ken 300, Japan ² T. NISHIKAWA MD, Assistant Professor of Anaesthesiology. Institute of Clinical Medicine, University of Tsukuba, 1–1–1 Tennodai, Tsukuba-shi, Ibaraki-ken 305, Japan.

KEYWORDS

Pharmacology; ephedrine, clonidine, vasopressors • Sympathetic nervous system; α₂-adrenergic agonist, clonidine, catecholamines

ABSTRACT

We studied pressor responses and changes in plasma catecholamine concentrations following two consecutive doses of ephedrine 0.1 mg.kg^-1 with (n = 20) and without (n = 20) clonidine 5 μg.kg^-1 premedication in patients presenting for a variety of major surgical procedures under general anaesthesia. Arterial blood pressure and heart rate were measured at 1 min intervals for 10 min, and plasma catecholamines were measured before and 3 min after each dose of ephedrine. Mean blood pressure changes from the baseline values were greater in the clonidine than in the control group 3–8 min and 4–9 min following the first and the second doses of ephedrine, respectively (p < 0.05). Plasma catecholamine concentrations tended to be lower in the clonidine group throughout the study. The augmented pressor response to ephedrine in clonidine-treated patients can be attributed to enhanced cardiovascular response rather than clonidine-induced accumulation and subsequent increased release of catecholamine.

Accepted 19 April 1995.

DIGITAL OBJECT IDENTIFIER (DOI)

10.1111/j.1365-2044.1996.tb07697.x About DOI