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Wiley InterScience | |||||||
  Alimentary Pharmacology & TherapeuticsVolume 10 Issue 4, Pages 523 - 527 Published Online: 2 Oct 2003 Journal compilation © 2010 Blackwell Publishing Ltd
Abstract | Full Text: PDF (Size: 200K) | Related Articles | Citation Tracking  Morning versus evening dosing of lansoprazole 30 mg daily on twenty-four-hour intragastric acidity in healthy subjects The study was supported by a grant from Lederle Laboratories. Clinical medical students from the Royal Free Hospital School of Medicine provided technical assistance. ABSTRACTBackground: Morning dosing is usually recommended with proton pump inhibitors, but there are few data from 24-h intragastric acidity studies comparing times of dosing. Methods: A double-blind, placebo-controlled study was performed on the seventh day of dosing to compare the effects of lansoprazole 30 mg given either in the morning or evening on 24-h intragastric acidity in 32 healthy volunteers. Results: The median integrated 24-h intragastric acidity on the seventh day of morning dosing with lansoprazole 30 mg was decreased to 36% of the placebo value, compared with 42% for evening dosing. For each daytime meal-related interval, morning dosing was significantly more effective for controlling acidity, but there was no significant difference between the regimens during the night interval (23.00–08.00 h). Conclusions: These data favour morning dosing of lansoprazole 30 mg for routine use, but patients with mainly nocturnal symptoms may be best treated by evening dosing.
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