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Wiley InterScience | |||||||||
  Clinical and Experimental DermatologyVolume 21 Issue 4, Pages 279 - 282 Published Online: 27 Apr 2006 Journal compilation © 2010 British Association of Dermatologists An Official Journal of the British Association of Dermatologists
Abstract | References | Full Text: PDF (Size: 1728K) | Related Articles | Citation Tracking  Reactive perforating collagenosis–transepidermal elimination of type IV collagen Copyright 1996 Blackwell Science Ltd ABSTRACT
Reactive perforating collagenosis (RPC) is a rare skin disorder characterized by reddish papules with a central keratotic plug which appear mainly on the extensor aspects of the limbs. An idiopathic or classical variant has been delineated from an acquired one which occurs in diabetes mellitus and renal failure. Histopathological examination of the lesions shows transepidermal elimination of abnormally staining bundles of collagen. To clarify the origin of this collagenous material we performed an immunohistochemical study including biopsies of two patients with RPC, one classical and one acquired. Staining reactivity to antibodies against type IV collagen was observed, thus providing evidence that the collagen eliminated in RPC may be derived from the basement membrane zone. Accepted for publication 3 May 1996 | 
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