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Wiley InterScience

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A Piroxicam Derivative Partly Effective in Chronic Paroxysmal Hemicrania and Hemicrania Continua
Dr. Ottar Sjaastad , MD, PhD Dr. Fabio Antonaci , MD
  From the Department of Neurology, Trondheim (Norway) University Hospitals and   the Headache Centre, "C. Mondino Foundation" University of Pavia, Italy.
Correspondence to Dr. Fabio Antonaci, Headache Centre, "C. Mondino Foundation" University of Pavia, via Palestro 3, 27100 Pavia, Italy.
Copyright © 1995 American Headache Society (formerly the American Association for the Study of Headache)
KEYWORDS
piroxicam • chronic paroxysmal hemicrania • hemicrania continua

ABSTRACT

Piroxicam beta-cyclodextrin has recently been observed to be equal to, or even possibly to be superior to, indomethacin (mainly with regard to side effects) in a single case of hemicrania continua. Piroxicam beta-cyclodextrin, 20 to 40 mg per day, was, accordingly, tried in six patients with chronic paroxysmal hemicrania and six patients with hemicrania continua with a previously proven response to indomethacin. The study was conducted over a period of 3 weeks and in an open fashion. A placebo effect is considered to be negligible in these disorders. In such a comparison, piroxicam beta-cyclodextrin seemed inferior to indomethacin, in particular in chronic paroxysmal hemicrania.


Accepted for publication April 12, 1995.

DIGITAL OBJECT IDENTIFIER (DOI)
10.1111/j.1526-4610.1995.hed3509549.x About DOI

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