A comparison of lansoprazole and ranitidine in the treatment of erosive oesophagitis

doi:10.1111/j.1365-2036.1995.tb00347.x

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Wiley InterScience

Alimentary Pharmacology & Therapeutics

Volume 9 Issue 1, Pages 25 - 31

Published Online: 31 Mar 2007

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A comparison of lansoprazole and ranitidine in the treatment of erosive oesophagitis

M. ROBINSON*, B. SAHBA†, D. AVNER‡, N. JHALA§, P. A. GRESKI-ROSE¶ D. E. JENNINGS¶

¹ Oklahoma City, OK †San Diego, CA ‡Salt Lake City, UT §Philadelphia, PA ¶TAP Pharmaceuticals Inc, Deerfield, IL, USA, on behalf of a multicentre investigational group

Correspondence to: Dr M. Robinson, Oklahoma Foundation for Digestive Research, University of Oklahoma Health Center, 711 Stanton Young Boulevard, Suite #501, Oklahoma City, OK 73104, USA

ABSTRACT

Background: Lansoprazole is a new proton pump inhibitor which produces prolonged decrease of gastric acidity. The aim of this study was to compare lansoprazole to a standard dose of ranitidine in the treatment of patients with reflux oesophagitis.

Methods: Two hundred and forty-seven patients with erosive oesophagitis were randomly assigned to 8 weeks of treatment with either 30 mg lansoprazole once daily or 150 mg ranitidine twice daily.

Results: Two hundred and forty-two patients were included in the analysis. Lansoprazole (30 mg) daily, healed oesophagitis in 92.1% of patients after 8 weeks of treatment. This was significantly superior to 150 mg ranitidine b.d.s. which healed oesophagitis in 69.9% of patients (P < 0.001). Relief of reflux symptoms was superior with lansoprazole to that with ranitidine. Both lansoprazole and ranitidine were well tolerated with no serious drug-related adverse events noted.

Conclusion: Lansoprazole, 30 mg once daily, is highly effective and safe in the short-term treatment of erosive oesophagitis.

Accepted for publication 21 September 1994

DIGITAL OBJECT IDENTIFIER (DOI)

10.1111/j.1365-2036.1995.tb00347.x About DOI