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Wiley InterScience | |||||||
  Clinical and Experimental Pharmacology and PhysiologyVolume 22 Issue s1, Pages S310 - S312 Published Online: 28 Jun 2007 Journal compilation © 2010 Blackwell Publishing Asia Pty Ltd
Abstract | References | Full Text: PDF (Size: 294K) | Related Articles | Citation Tracking  SESAME LIGNANS MODULATE CHOLESTEROL METABOLISM IN THE STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RAT Copyright 1995 Blackwell Publishing Asia Pty Ltd KEYWORDS acyl-CoA:cholesterol acyltransferase • apolipo-proteins • cholesterol 7α-hydroxylase • episesamin • lignans • lipoproteins • sesamin • stroke-prone spontaneously hypertensive rat ABSTRACT
1. Effects of sesamin and episesamin (an epimer of sesamin) on lipid metabolism, in particular cholesterol metabolism, were examined in normocholesterolaemic and hypercholestero-laemic stroke-prone spontaneously hypertensive rats (SHRSP). 2. In normocholesterolaemic SHRSP fed a regular diet, both sesamin and episesamin significantly increased the concentration of serum total cholesterol, which was due to an increase of high density lipoprotein (HDL) subfraction rich in apoE (apoE-HDL). In addition, both substances effectively decreased serum very low density lipoprotein (VLDL). In the liver, only episesamin significantly decreased the activity of microsomal acyl-CoA: cholesterol acyltransferase. 3. In hypercholesterolaemic SHRSP fed a high-fat and high-cholesterol diet (HFC diet), only episesamin improved serum lipoprotein metabolism with an increase in apoA-I and a decrease in apoB. In the liver, both sesamin and episesamin significantly suppressed cholesterol accumulation. Interestingly, only episesamin significantly increased the activity of microsomal cholesterol 7α-hydroxylase. 4. These results indicate that sesamin may be effective in preventing cholesterol accumulation in the liver. In comparison with sesamin, episesamin may be effective in the regulation of cholesterol metabolism in the serum and liver. Accepted for publication 10 July 1995. | 
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