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Wiley InterScience | |||||||||
  Clinical and Experimental DermatologyVolume 19 Issue 1, Pages 43 - 46 Published Online: 27 Apr 2006 Journal compilation © 2010 British Association of Dermatologists An Official Journal of the British Association of Dermatologists
Abstract | References | Full Text: PDF (Size: 266K) | Related Articles | Citation Tracking  Topical griseofulvin in the treatment of dermatophytoses Presented in part at the American Academy of Dermatology meeting, Dallas, TX, December 1991, the meeting of the International Society for Human Animal Mycology, Montreal, June 1991, and the 18th World Congress of Dermatology, New York, June 1992. Copyright 1994 Blackwell Science Ltd ABSTRACT
Whether griseofuilvin, which pioneered oral antifungal therapy, works topically has long been an open question. The effectiveness of a 1% griseofulvin spray formulation and the vehicle alone against experimentally induced Trichophyton mentagrphytes lesions on the forearms of 16 healthy volunteers and in the treatment of 100 tinea pedis patients (various dermatophytes) was evaluated in a double-blind study. After treatment of teh58 induced lesions twice daily for 14 days with topical griseofulvin (28) of placebo(30),80% of lesions receiving griseofulvin were mycologically negative compared with 30% in the placebo group (p<0.001), In the tinea pedis patients who applied medication once daily for 4 week and 80.9% 2 weeks post-treatment. Resurgence of dermatophytes quickly followed the end of treatment in the placebo group only, which had a mycological cure rate of 34%(week6) Administration of a ropical formulation of griseofulvin thus may be an effective treatment for interdigital dermatophyte infections. Accepted for publication 22 June 1993 | 
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