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Wiley InterScience | |||||||||||
  European Journal of Oral SciencesVolume 102 Issue 4, Pages 235 - 237 Published Online: 1 Oct 2007 Journal compilation © 2010 European Journal of Oral Sciences
Abstract | References | Full Text: PDF (Size: 3285K) | Related Articles | Citation Tracking  Effects of the β-adrenoceptor antagonists atenolol and propranolol on human unstimulated whole saliva flow rate and protein composition Copyright Munksgaard 1994 KEYWORDS atenolol • β-adrenoceptor antagonists • hypertension • propranolol • saliva ABSTRACTThe effects of 1-wk medication with two β-adrenoceptor antagonists on unstimulated whole saliva flow rate and protein composition were evaluated in 11 healthy young men in a randomized, double-blind, placebo-controlled, crossover study. Unstimulated whole saliva was collected before each treatment period and then again after 7 days. The saliva was assessed for flow rate, total protein, and hexosamine and sialic acid concentrations and for amylase activity. No significant effect on saliva secretion rate was found. A statistically significant reduction of salivary total proteins was registered during atenolol medication. The amylase activity decreased significantly during treatment with both atenolol and propranolol. Significant changes of the calculated ratios of sialic acid/hexosamine and hexosamine/total protein indicated an alteration in glandular protein synthesis after atenolol treatment. Accepted for publication 12 October 1993 | 
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