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Wiley InterScience | ||||||||||||
  AnaesthesiaVolume 47 Issue 4, Pages 303 - 306 Published Online: 22 Feb 2007 Journal compilation © 2010 The Association of Anaesthetists of Great Britain and Ireland Journal of the Association of Anaesthetists of Great Britain and Ireland
Abstract | References | Full Text: PDF (Size: 326K) | Related Articles | Citation Tracking  The relationship between the concentration of temazepam in cerebrospinal fluid and sedation in man Copyright 1992 The Association of Anaesthetists of Great Britain and Ireland KEYWORDS Hypnotics • benzodiazepines • temazepam •
Pharmacokinetics
• distribution ABSTRACT
Twenty-six patients received oral temazepam and subsequently spinal anaesthesia. Blood and lumbar cerebrospinal fluid temazepam levels were measured together with the degree of sedation. The plasma and cerebrospinal fluid concentrations correlated well with the temazepam dose but even better with the weight standardised dose (r = 0.65, p = 0.0003 and r = 0.75, p = p = 0.00001 respectively). Both the plasma and cerebrospinal fluid concentrations of temazepam were correlated with the patient's sedation (r = 0.42 p = 0.037, and r = 0.46 p = 0.021 respectively), but neither was strong. Thus, although the drug concentration at the receptor may be a major factor in producing sedation, others factors, possibly the receptor population or their responsiveness, are also important contributors. Accepted 8 August 1991 | 
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