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Wiley InterScience | |||||||
  British Journal of DermatologyVolume 127 Issue 4, Pages 403 - 406 Published Online: 29 Jul 2006 Journal compilation © 2010 British Association of Dermatologists An Official Journal of the British Association of Dermatologists
Abstract | References | Full Text: PDF (Size: 1671K) | Related Articles | Citation Tracking  Phenytoin-induced pseudolymphoma. A report of a case and review of the literature Copyright 1992 British Association of Dermatologists ABSTRACTSummary We report a patient with phenytoin-induced pseudolymphoma mimicking cutaneous T-cell lymphoma (CTCL). Despite withdrawal of phenytoin, there was persistence of the cutaneous eruption and lymphadenopathy. Southern blot analysis of immunoglobulin and T-cell receptor genes was therefore used to assess whether there was a clonal lymphoid expansion. However, no rearrangement of the beta T-cell receptor gene or immunoglobulin heavy-chain gene was detected in tissue DNA from skin and lymph nodes. One year later the patient became asymptomatic, although he is still at risk of developing a true malignant lymphoma in the future, a condition known as pseudo-pseudolymphoma. It is suggested that genotypic studies may help in the initial diagnosis and the subsequent management of such patients. Accepted for publication 1 May 1992 | 
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