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Wiley InterScience | ||||||||
  Alcoholism: Clinical and Experimental ResearchVolume 16 Issue 2, Pages 261 - 265 Published Online: 11 Apr 2006 © 2010 Research Society on Alcoholism
Abstract | References | Full Text: PDF (Size: 583K) | Related Articles | Citation Tracking  Effect of Fluoxetine on Alcohol Consumption in Male Alcoholics Editor's Note: This article was accepted for publication November 1990 and, unfortunately, was not processed at that time. We apologized to the authors for this delay. The time of publication should have been mid-1991. Presented in part at the AMSAODD/RSA combined annual meeting, San Francisco, California, April 1986, Alcohol Clin Exp Res 10:113, 1986. Supported by a grant from Lilly Research Laboratories to D.A.G. Copyright 1992 The Research Society on Alcoholism ABSTRACTTo test the effect of inhibiting serotonin uptake on voluntary alcohol intake, 20 alcohol-dependent males were housed on a locked hospital ward with 60-ml drinks of 97.5 proof alcohol available in a fixed interval drinking decision paradigm 13 times each day. After a 3-day, single-blind placebo baseline period, 10 subjects each received the serotonin uptake blocker fluoxetine (up to 80 mg po daily) or placebo double-blind for 28 days. The fluoxetine group had a 14% lower alcohol intake during the 1st week only, associated with a lower proportion of requests for alcohol and less craving for alcohol (as rated by research staff). There were no significant effects in later weeks, nor any differences in scores on the Hamilton Depression and Anxiety Scales or the Hopkins Symptom Checklist. Received for publication March 16, 1990; accepted November 9, 1990 | 
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