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Wiley InterScience | ||||||
  AddictionVolume 87 Issue 1, Pages 55 - 62 Published Online: 24 Jan 2006 Journal compilation © 2010 Society for the Study of Addiction Published on behalf of the Society for the Study of Addiction
Abstract | References | Full Text: PDF (Size: 1542K) | Related Articles | Citation Tracking  Assessment and management of opioid withdrawal symptoms in buprenorphine-dependent subjects Presented in part at the 52nd Annual Scientific Meeting of The Committee on Problems of Drug Dependence, Richmond, Virginia, June 10–14, 1990. Copyright 1992 Society for the Study of Addiction to Alcohol and Other Drugs ABSTRACT
The spontaneous physical dependence of buprenorphine was assessed in opioid addicts who switched from heroin to sublingual or intravenous buprenorphine. Twenty-two patients were randomly assigned to double-blind administration of methadone (n = 11) or placebo (n=11) for 13 days after abrupt withdrawal of buprenorphine. Methadone was administered according to four pre-established dosing schedules depending on the previous amount of daily consumed buprenorphine. No methadone-treated patient required modification of the therapeutic regimen, whereas eight of eleven placebo-treated patients needed treatment with methadone. Buprenorphine withdrawal syndrome was of opioid type, began somewhat more slowly, and showed a peak until day 5. The occurrence, time-course and characteristics of buprenorphine withdrawal syndrome make it necessary to reconsider the abuse potential of this analgesic. | 
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