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Wiley InterScience

Cephalalgia

Cephalalgia

Volume 11 Issue 2, Pages 93 - 95

Published Online: 19 Jan 2002

© 2009 International Headache Society



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Chocolate is a migraine-provoking agent
CM Gibb 1 , PTG Davies 2 , V Glover 1 , TJ Steiner 2 , F Clifford Rose 2 , M Sandler 1
  1 Bernhard Baron Memorial Research Laboratories, Queen Charlotte's and Chelsea Hospital, Goldhawk Road, London W6 0XG;   2 The Princess Margaret Migraine Clinic, Charing Cross Hospital, London W6 8RF
Correspondence to Merton Sandler, Bernhard Baron Memorial Research Laboratories, Queen Charlotte's and Chelsea Hospital, Goldhawk Road, London W6 0XG
Copyright International Headache Society
KEYWORDS
Chocolate • dietary migraine

ABSTRACT

Patients with migraine who believed that chocolate could provoke their attacks were challenged with either chocolate or a closely matching placebo. In a double-blind parallel group study, chocolate ingestion was followed by a typical migraine episode in 5 out of 12 patients, while none of the 8 patients challenged with placebo had an attack (p = 0.051). The median time to the onset of the attack was 22 h. This brief study provides some objective evidence that chocolate is able to provoke a migraine attack in certain patients who believe themselves sensitive to it.


Accepted 27 November 1990

DIGITAL OBJECT IDENTIFIER (DOI)
10.1046/j.1468-2982.1991.1102093.x About DOI

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