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Wiley InterScience | ||||||||||||||||
  Health Services ResearchVolume 43 Issue 1p1, Pages 32 - 53 Published Online: 26 Jun 2007 © 2010 Health Research and Educational Trust Published on behalf of Health Research and Educational Trust in cooperation with AcademyHealth.
Abstract | References | Full Text: HTML, PDF (Size: 148K) | Supporting Information | Related Articles | Citation Tracking  Just What the Doctor Ordered. Review of the Evidence of the Impact of Computerized Physician Order Entry System on Medication Errors Address correspondence to Tatyana. A. Shamliyan, M.D., M.S., Research Associate, Division of Health Policy and Management, University of Minnesota School of Public Health, MMC 729, 420 Delaware Street SE, Minneapolis, MN 55455. Sue Duval, Ph.D., Assistant Professor, is with the Division of Epidemiology, University of Minnesota School of Public Health, Minneapolis, MN. Jing Du, Graduate Student, is with the Division of Health Policy and Management, University of Minnesota School of Public Health, Minneapolis, MN. Robert L. Kane, M.D., Professor, is with the Division of Health Policy and Management, University of Minnesota School of Public Health, Minneapolis, MN. Copyright © 2007 Health Research and Educational Trust KEYWORDS Medication errors • medical order entry systems • epidemiologic studies ABSTRACTObjective. To examine the association between computerization of physician orders and prescribing medication errors. Data Sources. Studies published in English language were identified through MEDLINE (1990 through December 2005), Cochrane Central Register of Controlled Trials, and bibliographies of retrieved articles. Of 252 identified in the search, 12 (4.8 percent) original investigations that compared rates of prescribing medication errors with handwritten and computerized physician orders were included. Data Collection. Information on study design, participant characteristics, clinical settings, and outcomes rates were abstracted independently by two investigators using a standardized protocol. Principal Findings. Compared with handwritten orders, 80 percent of studies (8/10 studies) reported a significant reduction in total prescribing errors, 43 percent in dosing errors (3/7 studies), and 37.5 percent in adverse drug events (3/8 studies). The use of computerized orders was associated with a 66 percent reduction in total prescribing errors in adults (odds ratio [OR]=0.34; 95 percent confidence interval [CI] 0.22–0.52) and a positive tendency in children (p for interaction=.028). The benefit of computerized orders was larger when the rate of errors was more than 12 percent with handwritten orders (p for interaction=.022). Significant heterogeneity in the results compromised pooled relative risks. One randomized controlled intervention demonstrated the greatest benefits of computerized orders on total prescribing errors (OR=0.02, 95 percent CI 0.01–0.02) and dosing errors (OR=0.28; 95 percent CI 0.15–0.52) with 775 avoided prescribing errors (95 percent CI 752–811) per 1,000 orders in a pediatric hospital. Conclusions. Computerization of physicians' orders shows great promise. It will be more effective when linked to other computerized systems to detect and prevent prescribing errors. | 
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