Effects of Banana, Orange, and Apple on Oxidative Stress-Induced Neurotoxicity in PC12 Cells

doi:10.1111/j.1750-3841.2007.00632.x

If you are seeing this message, you may be experiencing temporary network problems. Please wait a few minutes and refresh the page. If the problem persists, you may wish to report it to your local Network Manager.

It is also possible that your web browser is not configured or not able to display style sheets. In this case, although the visual presentation will be degraded, the site should continue to be functional. We recommend using the latest version of Microsoft or Mozilla web browser to help minimise these problems.

Wiley InterScience

Journal of Food Science

Volume 73 Issue 2, Pages H28 - H32

Published Online: 24 Jan 2008

A Publication of the Institute of Food Technologists

Go to Society Site

< Previous Abstract

Save Article to My Profile Download Citation Request Permissions

Abstract | References | Full Text: HTML, PDF (Size: 255K) | Related Articles | Citation Tracking

Effects of Banana, Orange, and Apple on Oxidative Stress-Induced Neurotoxicity in PC12 Cells

H.J. Heo ¹ , S.J. Choi ¹ , S.-G. Choi ¹ , D.-H. Shin ¹ , J.M. Lee ¹ , and C.Y. Lee ¹

¹ Authors Heo and Choi are with Div. of Applied Life Science, Inst. of Agriculture and Life Sciences, Gyeongsang Natl. Univ., Jinju, Gyeongnam 660-701, Korea. Authors Choi and Shin are with Graduate School of Biotechnology, Korea Univ., Seoul 136-701, Korea. Author Lee is with Dept. of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee Univ., Yongin, Gyeonggi 449-701, Korea. Author Lee is with Dept. of Food Science and Technology, Cornell Univ., Geneva, N.Y. 14456, U.S.A. Direct inquiries to author Lee (E-mail: cyl1@cornell.edu).

KEYWORDS

apple • banana • neurotoxicity • orange • oxidative stress

ABSTRACT

ABSTRACT: Banana, orange, and apple are the major fruits in Western and Asian diets. In order to find the effects of these fruits, neuron like PC12 cells were exposed to the extracts of these fruits before H₂O₂ treatment. We found a significant viability of PC12 cells by the MTT reduction test, which indicated that the phenolics of banana, orange, and apple fruits prevented oxidative stress-induced neurotoxicity. Additional tests by lactate dehydrogenase and trypan blue exclusion assays showed that the extracts reduced oxidative stress-induced neuronal cell membrane damage. These results suggest that fresh apples, banana, and orange in our daily diet along with other fruits may protect neuron cells against oxidative stress-induced neurotoxicity and may play an important role in reducing the risk of neurodegenerative disorders such as Alzheimer's disease.

MS 20070602 Submitted 8/1/2007, Accepted 11/5/2007

DIGITAL OBJECT IDENTIFIER (DOI)

10.1111/j.1750-3841.2007.00632.x About DOI