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Wiley InterScience | ||||||||||
  HistopathologyVolume 52 Issue 4, Pages 436 - 444 Published Online: 29 Feb 2008 Journal compilation © 2010 Blackwell Publishing Ltd Published on behalf of the British Division of the International Academy of Pathology
Abstract | References | Full Text: HTML, PDF (Size: 1490K) | Related Articles | Citation Tracking  Light-chain-restricted germinal centres in reactive lymphadenitis: report of eight cases Copyright Journal compilation © 2008 Blackwell Publishing Ltd KEYWORDS autoimmune disease • light chain restriction • reactive lymphadenitis Nam-Cha S H, San-Millán B, Mollejo M, García-Cosio M, Garijo G, Gomez M, Warnke R A, Jaffe E S & Piris M A (2008) Histopathology52, 436–444 Light-chain-restricted germinal centres in reactive lymphadenitis: report of eight cases ABSTRACTAims: Light-chain-restricted germinal centres are generally associated with the existence of a neoplastic lymphoproliferative disorder. The aim was to present a series of cases with persistent lymph node enlargement that featured some germinal centres showing light chain immunoglobulin restriction. Methods and results: A series of six reactive lymphadenitis and two Castleman's disease cases was analysed by immunohistochemistry, IgH-polymerase chain reaction (PCR) and microdissected PCR. In all cases some germinal centres contained a population of plasma cells and plasmacytoid germinal centre cells showing light chain immunoglobulin restriction. In three cases the monotypic cells also showed distinct Bcl-2 expression. Two of the cases showed a predominant IgH rearrangement on a florid polyclonal background and one had an IgH monoclonal rearrangement, as revealed by PCR. Microdissected germinal centre PCR revealed a dominant repeated band in one of three cases and in another case a non-repeated clonal peak was observed. One of the patients developed a follicular lymphoma, which became evident from a subsequent biopsy. Conclusions: These findings may be a manifestation of an underlying disorder in the regulation of the immune response, or an exaggeration of the germinal centre oligoclonal nature. This should be taken into account in the differential diagnosis of follicular hyperplasia. | 
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