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Wiley InterScience | |||||||||||||
  European Journal of HaematologyVolume 80 Issue 4, Pages 287 - 295 Published Online: 21 Dec 2007 © 2010 John Wiley & Sons A/S
Abstract | References | Full Text: HTML, PDF (Size: 105K) | Related Articles | Citation Tracking  REVIEW ARTICLE Blood stem cell mobilization and collection in patients with lymphoproliferative diseases: practical issues Copyright Journal compilation © 2008 Blackwell Munksgaard KEYWORDS lymphoproliferative diseases • blood stem cell mobilization • collection • mobilization failure ABSTRACT
More than 15 000 autologous stem cell transplants (ASCT) were reported to European Blood and Bone Marrow Transplantation registry in 2005, most commonly for multiple myeloma (MM) and lymphomas. In 98% of the cases high-dose therapy was supported by blood stem cells. Thus stem cell mobilization and collection are integral parts of ASCT protocols. We give here a practical approach to blood stem cell mobilization and collection in patients with various lymphoproliferative diseases. While mobilization is usually easy and straightforward in patients with MM, about 10–20% of patients with non-Hodgkin's lymphoma or Hodgkin's lymphoma are hard-to-mobilize. There seems to be even more disease-specific issues in blood stem cell mobilization in patients with chronic lymphocytic leukaemia and in patients with light chain amyloidosis. We also discuss options in hard-to-mobilize patients. Accepted for publication 5 December 2007 | 
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