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Wiley InterScience | ||||||||||||||||
  Journal of Oral Pathology & MedicineVolume 37 Issue 2, Pages 83 - 87 Published Online: 26 Jul 2007 © 2010 John Wiley & Sons A/S
Abstract | References | Full Text: HTML, PDF (Size: 96K) | Related Articles | Citation Tracking  Simultaneous detection of IFN-gamma and IL-4 in lesional tissues and whole unstimulated saliva from patients with oral lichen planus Copyright 2007 The Authors. Journal compilation 2007 Blackwell Munksgaard KEYWORDS enzyme-linked immunosorbent assay • interferon-gamma • interleukin-4 • oral lichen planus • saliva ABSTRACTBackground: Although the roles of interferon (IFN)-gamma and interlekin (IL)-4 in oral lichen planus (OLP) have been described extensively in past decades, the available results are controversial. Moreover, few studies have utilized simultaneous detection of cytokines in local tissues and saliva to determine whether salivary cytokines could reflect the fact of local lesions. Methods: IFN-gamma and IL-4 were determined simultaneously in lesions and whole unstimulated saliva (WUS) from OLP patients with various clinical forms. Results: In OLP lesions, both IFN-gamma and IL-4 in erythematous/ulcerated OLP were higher significantly than that in control specimens. In WUS, however, only IFN-gamma of erythematous/ulcerated OLP was increased compared with control. Remarkably, IFN-gamma and IL-4 in WUS showed a more significant correlation to those in local tissues of all subjects. Conclusion: These results indicate that both IFN-gamma and IL-4 may play more important role in pathogenesis of erythematous/ulcerated OLP, and changes of these proinflammatory cytokines in WUS may reflect the status of the OLP lesion. Accepted for publication May 22, 2007 | 
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 | Journal of Oral Pathology and Medicine |
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