Naproxen Sodium for Muscle Contraction Headache Treatment

doi:10.1111/j.1526-4610.1988.hed2803180.x

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Wiley InterScience

Headache: The Journal of Head and Face Pain

Volume 28 Issue 3, Pages 180 - 182

Published Online: 22 Jun 2005

Published on behalf of the American Headache Society

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Naproxen Sodium for Muscle Contraction Headache Treatment

Joseph D. Sargent , M.D. ¹ Kenneth Peters , M.D. ² Jerome Goldstein , M.D. ³ David S. Madison , M.D. Patricia Solbach , Ph.D. ⁴

¹ Co-Director, Headache and Internal Medicine Research Center, Chief of Internal Medicine, Menninger Clinic, Topeka, KS ² Medical Director, Northern California Headache Clinic, Mountain View, CA ³ Medical Director, San Francisco Headache Clinic, San Francisco, CA ⁴ Co-Director, Headache and Internal Medicine Research Center, Menninger Clinic, Topeka, KS

The work presented was based on the administration of Anaprox^(r) (naproxen sodium) capsules; Anaprox is a registered trademark of Syntex Laboratories, Inc.

ABSTRACT

SYNOPSIS

In this multicenter, double-blind, parallel study, patients with muscle contraction headache were randomized to treatment with either two naproxen sodium 275 mg capsules per headache or matching placebo. Of a total of 161 patients enrolled, 137 received trial medication and 134 (63 taking naproxen sodium and 71 taking placebo) were valid for efficacy analysis. During four headache episodes, patients recorded, on a visual analog scale, pain intensity just before the dose of trial medication (baseline) and at1, 2, and 4 hours after this dose. For each patient, two additional indices were derived from these data: Pain Intensity Difference (PID), the difference between intensity of pain at baseline and intensity of pain recorded at any time after treatment began; and Summed Pain Intensity Difference (SPID), the sum of the PIDs at a given hour. Results significantly favored naproxen sodium over placebo (p<0.05) at all times. Naproxen sodium was found to be well tolerated and was more efficacious than placebo in the treatment of muscle contraction headache.

Accepted for Publication: February 4, 1988

DIGITAL OBJECT IDENTIFIER (DOI)

10.1111/j.1526-4610.1988.hed2803180.x About DOI