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Wiley InterScience | ||||||||||||||
  Journal of NeurochemistryVolume 50 Issue 1, Pages 69 - 74 Published Online: 12 Dec 2006 Journal compilation © 2010 International Society for Neurochemistry Published for the International Society for Neurochemistry
Abstract | References | Full Text: PDF (Size: 1146K) | Related Articles | Citation Tracking  Neuritic Plaque Amyloid in Alzheimer's Disease Is Highly Racemized Copyright 1988 International Society for Neurochemistry KEYWORDS Alzheimer's disease • Amino acids • Racemization • Amyloid • Neuritic plaques • Senile plaques ABSTRACTAbstract: Neuritic plaque core amyloid protein in Alzheimer's disease brain tissue was investigated for the extent of amino acid racemization. Long-lived human proteins exhibit racemization of certain amino acids over the course of a human lifetime. Purified core amyloid was found to contain relatively large proportions of D-aspartate and D-serine, suggesting that neuritic plaque amyloid is derived from a long-lived precursor protein. Alternatively, racemization of protein amino acids may be abnormally accelerated in Alzheimer's disease. Received December 30, 1986; revised manuscript received June 1, 1987; accepted July 14, 1987. | 
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