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Wiley InterScience | |||||||||||
  Dental TraumatologyVolume 4 Issue 3, Pages 132 - 137 Published Online: 27 Apr 2006 © 2010 John Wiley & Sons A/S Official Publication of the International Association for Dental Traumatology and the International Academy of Sports Dentistry
Abstract | References | Full Text: PDF (Size: 7288K) | Related Articles | Citation Tracking  Ciprofloxacin treatment of periapical Pseudomonas aeruginosa infection Copyright Munksgaard 1988 KEYWORDS Ciprofloxacin • apical periodontitis •
Pseudomonas aeruginosa infection ABSTRACTSurvival of bacteria in periapical tissues may be the reason for endodontic failures. This case report describes the treatment of a patient with periapical lesions refractory to endodontic treatment. Microbiological sampling from fistulae associated with the lesions revealed the presence of Pseudomonas aeruginosa. Phenoxymethyl penicillin, metronidazole and carbenicillin were ineffective in eliminating the periapical infection. However, an investigational antibiotic, Ciprofloxacin, which was administered orally twice daily for 15 weeks, proved to be an effective, safe and convenient medicament in the treatment of periapical Pseudomonas aeruginosa infection. The fistulae closed in less than 2 weeks and a radiograph taken during the fourteenth week of therapy showed healing of the apical periodontitis with osseous regeneration. It is suggested that Ciprofloxacin is a valuable agent in the treatment of apical periodontitis, and probably other odontogenic infections caused by susceptible aerobic gram-negative bacilli. Accepted for publication 4 January 1988. | 
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