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BUPIVACAINE ACUTE TOXICITY PROTECTION BY DIAZEPAM IN MICE
B. Bruguerolle* , a , N. Emperaire † , A. Ottomani † J. C. Manelli †
 *Laboratoire de Pharmacologie Médicale, Faculté de Médecine, Marseille   †Departement d'Anesthésie-Réanimation, Hôpital de la Conception, Marseille, France
Correspondence to   a Dr. B. Bruguerolle, Laboratoire de Pharmacologie Médicale, Faculté de Médecine de Marseille, 27 Bd J. Moulin F 13385 Marseille cedex 5, France.
Copyright 1988 Blackwell Publishing Asia Pty Ltd

ABSTRACT

AbstractReferences

1. The effects of acute and 8-day administration of diazepam (DZP) on the acute toxicity of bupivacaine in the mouse were studied.

2. Protection of bupivacaine-induced acute toxicity by DZP appears to be dose-dependent after treatment for 8 days but not after acute treatment.

(Received 27 January 1988)

DIGITAL OBJECT IDENTIFIER (DOI)
10.1111/j.1440-1681.1988.tb01114.x About DOI

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