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Wiley InterScience | ||||||
  AddictionVolume 83 Issue 5, Pages 581 - 585 Published Online: 24 Jan 2006 Journal compilation © 2010 Society for the Study of Addiction Published on behalf of the Society for the Study of Addiction
Abstract | References | Full Text: PDF (Size: 1429K) | Related Articles | Citation Tracking  Alprazolam Versus Chlormethiazolc in Acute Alcohol Withdrawal Copyright 1988 Society for the Study of Addiction to Alcohol and Other Drugs ABSTRACT
In this 7-day, double-blind, parallel-group study of patients undergoing acute alcohol withdrawal, alprazolam and chlonnethiazole were equally effective as rated by both patients and physician. The starting doses were alprazolam 4 mg/day and chlormethiazole base 3.072 g/day (equivalent to 8g of the edisylate) and a specific tapered dosage regimen teas adhered to. Patients received study medication on days 1-S; no study medication was given on days 6 and 7. Of the 102 patients who participated in the study, 90 were considered evaluable for efficacy; all available data were included in safety analyses. There was some evidence that alprazolam produced a faster response and was more effective than cklormethiasole in controlling tremor. One patient, in the chlormethiazole group, withdrew from the study early because of side effects (allergic reaction). One alprazolam-treaced patient had a generalized seizure on day 3 that required treatment with diazepam and carbamazepine, but the patient remained in and completed the study. | 
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