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Phenytoin potentiates accessory cell dependent DNA-synthesis in human lymphocytes in vitro
GÖRAN DAHLLÖE 1 , PER OTTESKOG 1 THOMAS MODÉER 1
  1 Department of Pedodontics and the Clinical Research Unit, School of Dentistry, Karolinska Institutet, Stockholm, Sweden
Correspondence to  Goran Dahllöf, Department of Pedodontics, Odontological Clinics, S-141 04 Huddinge, Sweden.
Copyright Munksgaard 1986
KEYWORDS
lymphocytes • mitogen stimulation • phenytoin

ABSTRACT

Abstract —The effect of phenytoin and its major metabolite p-HPPH on concanavalin A (ConA) induced DNA-synthesis of human lymphocytes was studied in vitro. In lymphocyte cultures depleted of phagocytizing cells by iron treatment PHT and p-HPPH, in pharmacologic concentrations, caused a depression of the mitogen response measured as uptake of 3H-thymidine. In contrast, the presence of phagocytizing mononuclear cells during ConA-stimulation in the presence of PHT and p-HPPH caused a potentiation of ConA induced DNA-synthesis. These effects of phenytoin on immunocampetent cells may be of significance in the pathogenesis of the PHT-induced gingival overgrowth, since earlier we have reported the presence of large infiltrates of lymphocytes, mainly T-lymphocytes in gingival biopsies from clinically non-inflamed PHT-induced gingival overgrowth.

Accepted for publication 9 August 1985.

DIGITAL OBJECT IDENTIFIER (DOI)
10.1111/j.1600-0722.1986.tb01754.x About DOI

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