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Wiley InterScience | |||||||||
  British Journal of DermatologyVolume 113 Issue 6, Pages 731 - 735 Published Online: 29 Jul 2006 Journal compilation © 2010 British Association of Dermatologists An Official Journal of the British Association of Dermatologists
Abstract | References | Full Text: PDF (Size: 286K) | Related Articles | Citation Tracking  Oral acyclovir in the suppression of recurrent non-genital herpes simplex virus infection Copyright 1985 British Association of Dermatologists ABSTRACT
In a double-blind, placebo-controlled, cross-over trial in 11 patients suffering eight or more episodes of recurrent non-genital herpes simplex virus (HSV) infection per annum, only two patients experienced a recurrence during treatment with oral acyclovir (200 mg 4 times daily) for up to 12 weeks, compared with nine during placebo treatment (P=0.016). Although lesion development was effectively suppressed in nine of the patients whilst taking acyclovir, the development of prodromal symptoms, and occasionally erythema, was reported by five. There was no difference between acyclovir and placebo in the time to the next recurrence following completion of treatment. No patient reported any side effects of either placebo or acyclovir therapy. It is believed that this is the first report of any form of oral therapy which is effective in suppressing recurrent non-genital HSV infection in immunocompetent patients. Accepted for publication 20 June 1985 | 
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