Amerlex free triiodothyronine and free thyroxine levels in normal pregnancy

doi:10.1111/j.1471-0528.1985.tb04868.x

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Wiley InterScience

BJOG: An International Journal of Obstetrics & Gynaecology

Volume 92 Issue 12, Pages 1234 - 1238

Published Online: 23 Aug 2005

Published on behalf of the Royal College of Obstetricians and Gynaecologists

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Amerlex free triiodothyronine and free thyroxine levels in normal pregnancy

JOHN H. PARKER Principal Biochemist ¹

¹ Department of Pathology, Royal Shrewsbury Hospital, Mytton Oak Road, Shrewsbury SY3 8XH.

ABSTRACT

Summary. Free triiodothyronine (FT₃) and free thyroxine (FT₄) were measured in 159 women during normal pregnancy and compared with non-pregnancy reference ranges for these hormones. FT₃ values fell from the reference level of 6·34 (SD 1·06) pmol/l to 3·87 (SD 0·54) pmol/l in the 3rd trimester; corresponding figures for FT₄ were: reference 16·92 (SD 2·97) pmol/l, 3rd trimester 11·29 (SD 2·01) pmol/l. There were no significant changes in the 1st trimester; 4% and 69% of FT₃ results in the 2nd and 3rd trimesters respectively fell below the reference range of mean ±2 SD. The corresponding findings for FT₄ were 4% and 42%. FT₃ correlated reasonably well with total T₃ (r=0·90) and was acceptably precise (within-batch CV 2·1% at 5·6 pmol/l, between-batch CV between 3·1% and 4·7% at six levels).