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Wiley InterScience

BJOG: An International Journal of Obstetrics & Gynaecology

BJOG: An International Journal of Obstetrics & Gynaecology

Volume 92 Issue 9, Pages 983 - 985

Published Online: 23 Aug 2005

Journal compilation © 2010 RCOG



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Spironolactone in combination with an oral contraceptive: an alternative treatment for hirsutism
M. G. CHAPMAN Lecturer 1 , M. DOWSETT Senior Biochemist 1 , C. J. DEWHURST Professor of Obstetrics and Gynaecology 1 S. L. JEFFCOATE Professor of Biochemical Endocrinology 1
  1 Institute of Obstetrics and Gynaecology, Chelsea Hospital for Women
 Correspondence: M. G Chapman, Department Obstetrics & Gynaecology, Guy's Hospital Medical School, St Thomas Street, London SEl9RT.
Copyright RCOG 1985 BJOG: an International Journal of Obstetrics and Gynaecology

ABSTRACT

Summary. The clinical efficacy of a combination of spironolactone and an oral contraceptive pill (Conova 30) was assessed in 23 patients presenting with hirsutism of whom 20 completed 6 months of treatment. Of the 20 patients, 16 showed improvement on objective (Ferriman & Gallwey hair score) and subjective assessment. Serum levels of androgens (testosterone, androstenedione and 17-hydroxy progesterone) were suppressed and sex hormone binding globulins were elevated. Nausea was the only significant side effect.


Received 8 June 1984Accepted 20 February 1985

DIGITAL OBJECT IDENTIFIER (DOI)
10.1111/j.1471-0528.1985.tb03081.x About DOI

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