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Wiley InterScience

Clinical and Experimental Dermatology

Clinical and Experimental Dermatology

Volume 10 Issue 3, Pages 194 - 200

Published Online: 27 Apr 2006

Journal compilation © 2010 British Association of Dermatologists



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Methotrexate maintenance therapy and liver damage in psoriasis
P.C.M. VAN DEKERKHOF 1 , W.H.L. HOEFNAGELS*, U.J.G.M. VANHAELST J.W.H. MALI 1
  1 Department of Dermatology, University of Nijmegen, The Netherlands   *Department of Medicine; Division of General Internal Medicine, University of Nijmegen, The Netherlands   Department of Pathology, University of Nijmegen, The Netherlands
Copyright 1985 Blackwell Science Ltd

ABSTRACT

AbstractReferences

In this communication we report our data on classification of liver biopsies taken from 44 psoriatic patients who had been receiving methotrexate maintenance therapy (Weinstcin regime) for long periods. In this series 4·5% showed cirrhosis and 15·9% fibrosis of the liver. There was no correlation between liver biopsy classification and either the cumulative dose or the duration of methotrexate therapy. A highly significant correlation has been shown between liver damage and the age of the patients.


Accepted for publication 28 November 1984

DIGITAL OBJECT IDENTIFIER (DOI)
10.1111/j.1365-2230.1985.tb00558.x About DOI

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