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Wiley InterScience

Anaesthesia

Anaesthesia

Volume 38 Issue 1, Pages 40 - 43

Published Online: 22 Feb 2007

Journal compilation © 2010 The Association of Anaesthetists of Great Britain and Ireland



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Adverse reactions to intravenous codeine phosphate in children
A report of three cases
E. C. SHANAHAN 1 A. G. MARSHALL 1 C. P. O. GARRETT 1
  1 E.C. Shanahan, MB, BCh, BAO, FFARCS, Senior Registrar and Clinical Lecturer in Anaesthesia, University College Hospital, A.G. Marshall, BSc, MB, ChB, FFARCS, Senior Registrar in Anaesthesia, The London Hospital, C.P.O. Garrett, BSc. MB, BS. FFARCS, Senior Registrar in Anaesthesia, University College Hospital, London WC1E 6JJ.
Copyright 1983 The Association of Anaesthetists of Great Britain and Ireland
KEYWORDS
Allergy; codeine phosphate

ABSTRACT

AbstractReferences

Adverse reactions ranging from tachycardia and cutaneous vasodilatation to severe hypotension and apnoea occurred in three children who were given codeine phosphate intravenously. The cause of these reactions is discussed and a review of the literature on the parenteral use of codeine phosphate is presented. The findings indicate that the standard reference formularies and pharmacopeoiae, with one exception, deal inadequately with the parenteral use of codeine phosphate. On the evidence of the cases presented we would support the conclusion of the American Medical Association's drug evaluations, that codeine phosphate should not be used intravenously in children.


DIGITAL OBJECT IDENTIFIER (DOI)
10.1111/j.1365-2044.1983.tb10371.x About DOI

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